InFocus is a Photoshop PlugIn that uses deconvolution to sharpen images by refocusing. Different from edge methods like unsharp masking. Back in my microscopy days, these methods were just starting to come into use, often with the use of multiple focus planes for virtual confocal microscopy.
This is not the best example as a photo, since the water is causing blur in this photo, but a good test of how this PlugIn works to recover detail.